Recall Alert of Substandard batches of Lowplat plus Tablets || Issued by DDC punjab

Lowplat Plus Tablet is a film-coated, bi-layered antiplatelet medicine containing Clopidogrel Bisulphate 75 mg and Aspirin 75 mg. It is manufactured by M/s PharmEvo (Pvt.) Ltd., Karachi, and is registered under Reg. No. 047177.

The Punjab Drug Testing Laboratory has declared certain batches of Lowplat Plus substandard based on impurity testing, resulting in an official recall of the affected batches.

Sub-standard drug” means a drug which is not of specifications.

Medicine Recall Alert — Class II

Government of the Punjab | Directorate of Drugs Control (DDC), Punjab
DDCP Alert No.: 144/2026
Date: 05 October 2026

Product Recalled

Product: Tablet Lowplat Plus
Composition per tablet:
- Clopidogrel Bisulphate 75 mg
- Aspirin 75 mg
Dosage form: Film-coated, bi-layered tablet
Reg. No.: 047177
Manufacturer: M/s PharmEvo (Pvt.) Ltd.
Address: Plot # A-29, Northern Western Industrial Zone, Port Qasim, Karachi-75020

Affected Batches

The following batches have been declared Substandard:

6B300 — Expiry: January 2028
6B301 — Expiry: January 2028
6B268 — Expiry: January 2028
6B277 — Expiry: January 2028
6C135 — Expiry: February 2028
6C136 — Expiry: February 2028
6C137 — Expiry: February 2028
6C138 — Expiry: February 2028
6C269 — Expiry: February 2028
6C270 — Expiry: February 2028

Reason for Recall

The Drug Testing Laboratory Punjab declared the above batches Substandard based on Impurities Test results.
The Provincial Quality Control Board, Punjab has directed that these batches be recalled from the market.
The recall relates specifically to the batches listed above.

Instructions for Pharmacies, Distributors & Healthcare Facilities

Immediately stop dispensing/selling the affected batches.
Separate and secure any remaining stock.
Report current inventory and consumption records to the relevant:
- Area Drug Inspector
- Drug Inspector (Distributor)
- Drug Inspector (Health Facility)
Healthcare and drug-control personnel are directed to strengthen surveillance throughout the supply chain.

Advice for Healthcare Professionals & Regulators

Take appropriate regulatory action in accordance with the Drugs Act 1976, DRAP Act 2012, and applicable rules.
Submit comprehensive reports to the Chief Drugs Controller, Punjab for onward submission to the concerned authorities.

Instructions to Manufacturer / MAH / Distributor

Immediately initiate recall of the affected batches.
Provide the complete distribution trail.
Upload the Recall Assessment Form on the DRAP website.
Conduct a detailed Root Cause Analysis (RCA).
Prepare a Corrective and Preventive Action (CAPA) plan.
Submit all required actions and supporting documents to DRAP/the competent authority.

Advice for Patients / General Public

Stop using the affected batches immediately.
Patients should check the batch number on their Lowplat Plus packaging against the list above.
The alert states that continued use of the affected batches may pose a risk to health.
In case of any adverse effect associated with these batches, report it through the Medicine Surveillance System (MSS) at the Punjab Pharmacovigilance Centre.

Reporting / Contact

Directorate of Drugs Control (DDC), Punjab

Phone: +92-42-99268498
Email: p&pvddcp.pshealth@punjab.gov.pk
Medicine Surveillance System: mss.pshealth.punjab.gov.pk